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Angela Hayes Selected Research

PI 540

7/2009Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941.

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Angela Hayes Research Topics

Disease

26Neoplasms (Cancer)
02/2021 - 07/2004
4Carcinoma (Carcinomatosis)
12/2011 - 07/2004
4Colonic Neoplasms (Colon Cancer)
12/2011 - 04/2007
2Neoplasm Metastasis (Metastasis)
10/2019 - 04/2008
2Melanoma (Melanoma, Malignant)
04/2008 - 03/2007
2Alzheimer Disease (Alzheimer's Disease)
07/2005 - 05/2004
1Lymphoma (Lymphomas)
01/2022
1Starvation
01/2022
1Rhabdomyosarcoma
01/2022
1Residual Neoplasm
02/2021
1Prostatic Neoplasms (Prostate Cancer)
02/2021
1Margins of Excision
02/2021
1Autoimmune Diseases (Autoimmune Disease)
01/2021
1Genetic Translocation (Chromosomal Translocation)
01/2021
1Triple Negative Breast Neoplasms
10/2019
1Breast Neoplasms (Breast Cancer)
01/2019
1Diffuse Intrinsic Pontine Glioma
01/2019
1Colorectal Neoplasms (Colorectal Cancer)
04/2017
1Aneuploidy (Aneuploid)
04/2017
1Chromosomal Instability (Chromosome Stability)
04/2017
1B-Cell Lymphoma (Lymphoma, B Cell)
01/2016
1Neuroblastoma
10/2012
1Glioblastoma (Glioblastoma Multiforme)
07/2009
1Lymphatic Metastasis
04/2008
1Hypoxia (Hypoxemia)
04/2008
1Ovarian Neoplasms (Ovarian Cancer)
06/2007
1Glioma (Gliomas)
06/2007

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
01/2021 - 05/2004
4GemcitabineFDA Link
01/2016 - 01/2010
3Irinotecan (Camptosar)FDA LinkGeneric
01/2022 - 12/2011
3Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2019 - 01/2005
3Phosphotransferases (Kinase)IBA
01/2019 - 04/2017
3Biomarkers (Surrogate Marker)IBA
01/2016 - 06/2007
3Heat-Shock Proteins (Heat-Shock Protein)IBA
12/2011 - 06/2006
2BOS172722IBA
10/2019 - 01/2018
23- ((1- (dimethylamino)propan- 2- yl)oxy)- 5- ((4- methoxy- 5- (1- methyl- 1H- pyrazol- 4- yl)pyridin- 2- yl)amino)pyrazine- 2- carbonitrileIBA
11/2012 - 10/2012
2Biological ProductsIBA
12/2011 - 06/2007
2RoscovitineIBA
11/2011 - 01/2005
2Molecular Chaperones (Chaperone, Molecular)IBA
08/2009 - 01/2008
2PI103IBA
07/2009 - 06/2007
22- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA
07/2009 - 09/2008
2IsoxazolesIBA
04/2008 - 04/2007
25- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamideIBA
04/2008 - 01/2008
2Pharmaceutical PreparationsIBA
04/2008 - 06/2007
2CCT018159IBA
03/2007 - 06/2006
1Mitogen-Activated Protein KinasesIBA
01/2022
1Messenger RNA (mRNA)IBA
01/2022
1ponatinibIBA
01/2022
1Type 4 Fibroblast Growth Factor ReceptorIBA
01/2022
14- amino- 5- fluoro- 3- (5- (4- methylpiperazin- 1- yl)- 1H- benzimidazol- 2- yl)quinolin- 2(1H)- oneIBA
01/2022
1nintedanibIBA
01/2022
1LigandsIBA
01/2022
1infigratinibIBA
01/2022
1CCT373566IBA
01/2022
1Culture MediaIBA
01/2022
1Docetaxel (Taxotere)FDA Link
02/2021
1AntigensIBA
01/2021
1Histones (Histone)IBA
10/2019
1Paclitaxel (Taxol)FDA LinkGeneric
10/2019
1Estrogen ReceptorsIBA
01/2019
1Progesterone Receptors (Progesterone Receptor)IBA
01/2019
1dipinacoline glutamateIBA
01/2019
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2019
1AntibodiesIBA
04/2017
1CCT271850IBA
04/2017
1Transcription Factors (Transcription Factor)IBA
08/2016
1CCT245737IBA
01/2016
1Adenosine Triphosphate (ATP)IBA
12/2013
1Peptides (Polypeptides)IBA
12/2013
1Protein Kinases (Protein Kinase)IBA
12/2013
1isoquinolineIBA
12/2011
1LactonesIBA
12/2011
1NitrogenIBA
12/2011
1Macrocyclic LactamsIBA
12/2011
1AcidsIBA
12/2011
1monorden (radicicol)IBA
12/2011
1Cyclin EIBA
11/2011
1CCT68127IBA
11/2011
14- fluoro- 2- (4- (4- (2- hydroxypropan- 2- yl)pyrrolidin- 3- ylamino)- 6,7- dimethoxyquinazolin- 2- yl)phenolIBA
01/2011
1Drug CombinationsIBA
01/2010
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2010
1Etoposide (VP 16)FDA LinkGeneric
01/2010
1Antineoplastic Agents (Antineoplastics)IBA
01/2010
1PI 540IBA
07/2009
1PI 620IBA
07/2009
1Protein Isoforms (Isoforms)IBA
07/2009
1Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
09/2008
1pyrimidineIBA
09/2008
1Cyclin-Dependent Kinase 4IBA
04/2008
1Therapeutic UsesIBA
04/2008
1LipidsIBA
06/2007
1VER-49009IBA
04/2007
1VER-50589IBA
04/2007
1HSP72 Heat-Shock ProteinsIBA
03/2007
1LDL Receptors (LDL Receptor)IBA
07/2005

Therapy/Procedure

4Therapeutics
02/2021 - 06/2006
2Drug Therapy (Chemotherapy)
11/2012 - 01/2010
1Prostatectomy (Retropubic Prostatectomy)
02/2021
1Transjugular Intrahepatic Portasystemic Shunt
02/2021
1Oral Administration
10/2012